Assays for genetic dissection of septin filament assembly in yeast, from de novo folding through polymerization.

Abstract excerpt

In Saccharomyces cerevisiae, septin mutations have severe effects on colony-forming ability, particularly at high temperatures, allowing the full variety of genetic tools available in this model organism to be applied to the study of septin biology. Although many details of septin function remain unknown, one can exploit a small number of easily scored phenotypes-proliferation capacity, cell morphology, septin...

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