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Complex chromosomal rearrangements leading to <scp><i>MECOM</i></scp> overexpression are recurrent in myeloid malignancies with various 3q abnormalities

27 Jan 2016

Abstract excerpt

Chromosomal rearrangements involving 3q26 are recurrent findings in myeloid malignancies leading to MECOM overexpression, which has been associated with a very poor prognosis. Other 3q abnormalities have been reported and cryptic MECOM rearrangements have been identified in some cases. By fluorescence in situ hybridization (FISH) analysis, we investigated 97 acute myeloid leukemia/myelodysplastic syndrome...

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PMID: 26815134
DOI: 10.1002/gcc.22341

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