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Article

Let's stick together: The role of the Fras1 and Frem proteins in epidermal adhesion

1 Jan 2007

Abstract excerpt

The Fras1 and Frem extracellular matrix proteins play critical roles in epithelial-mesenchymal interaction during embryonic development. Loss of function in humans results in a recessive embryonic blistering disorder called Fraser syndrome. Inactivation of these proteins, or the proteins with which they interact (e.g., Grip1) has also been shown to underlie members of the 'bleb' family of classic mouse mutants...

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PMID: 17654118
DOI: 10.1080/15216540701510581

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Let's stick together: The role of the Fras1 and Frem proteins in epidermal adhesionPMID 17654118Read ↗

The Fras1/Frem family of extracellular matrix proteins: structure, function, and association with Fraser syndrome and the mouse bleb phenotype.Semantic proximity Read ↗

The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.Semantic proximity Read ↗

The role of Fras1/Frem proteins in the structure and function of basement membrane.Semantic proximity Read ↗

The genetics of Fraser syndrome and the blebs mouse mutantsSemantic proximity Read ↗

Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.Semantic proximity Read ↗

Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.Semantic proximity Read ↗

Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.Semantic proximity Read ↗

bfb, a novel ENU-induced blebs mutant resulting from a missense mutation in Fras1.Semantic proximity Read ↗

Mutations in GRIP1 cause Fraser syndrome.Semantic proximity Read ↗

<i>Frem2</i> Knockout Mice Exhibit Fraser Syndrome Phenotypes and Neonatal Lethality Due to Bilateral Renal AgenesisSemantic proximity Read ↗

AMACO is a component of the basement membrane-associated Fraser complex.Semantic proximity Read ↗

Kindler syndrome: a focal adhesion genodermatosis.Semantic proximity Read ↗

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