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Article

[Hereditary non-polyposis colorectal cancer. Report of four siblings].

Revista medica de Chile - 1 Jun 2008

Zárate Alejandro, Alvarez Karin, Wielandt Ana María, Hevia Montserrat, De la Fuente Marjorie, Carvallo Pilar, López-Köstner Francisco

Abstract excerpt

Hereditary non-polyposis colorectal cancer (HNPCC) or Lynch Syndrome is an autosomic dominant syndrome involving 596-1096 of colorectal cancer patients. Mutations in MLH1 and MSH2 genes account for most cases. These two genes participate in the DNA mismatch repair pathway. Therefore mutation carr...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Adenocarcinoma
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microsatellite Instability

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

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Source

Identifiers

PMID: 18769833
DOI: /S0034-98872008000600011

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18769833-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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