Article
Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action.
Molecular and cellular endocrinology - 15 Mar 2016
Marelli Federica, Carra Silvia, Agostini Maura, Cotelli Franco, Peeters Robin, Chatterjee Krishna, Persani Luca
Abstract excerpt
Resistance to thyroid hormone can be due to heterozygous, dominant negative (DN) THRA (RTHα) or THRB (RTHβ) mutations, but the underlying mechanisms are incompletely understood. Here, we delineate the spatiotemporal expression of TH receptors (TRs) in zebrafish and generated morphants expressing equivalent amounts of wild-type and DN TRαs (thraa_MOs) and TRβs (thrb_MOs) in vivo. Both morphants show severe...
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