Article
Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial cancer.
Molecular and cellular endocrinology - 15 Mar 2016
Shafiee Mohamad Nasir, Seedhouse Claire, Mongan Nigel, Chapman Caroline, Deen Suha, Abu Jafaru, Atiomo William
Abstract excerpt
BACKGROUND: Endometrial cancer (EC) is the most common gynaecological cancer amongst women in the UK. Although previous studies have found that women with polycystic ovary syndrome (PCOS) have at least a three-fold increase in endometrial cancer (EC) risk compared to women without PCOS, the precise molecular mechanisms which link between PCOS and EC remain unclear. It has been suggested that insulin resistance...
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