Article
PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin.
Reproductive biology and endocrinology : RB&E - 11 May 2023
Wilson Mike R, Harkins Shannon, Reske Jake J, Siwicki Rebecca A, Adams Marie, Bae-Jump Victoria L, Teixeira Jose M, Chandler Ronald L
Abstract excerpt
Endometrial epithelia are known to harbor cancer driver mutations in the absence of any pathologies, including mutations in PIK3CA. Insulin plays an important role in regulating uterine metabolism during pregnancy, and hyperinsulinemia is associated with conditions impacting fertility. Hyperinsulinemia also promotes cancer, but the direct action of insulin on mutated endometrial epithelial cells is unknown. Here,...
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