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Article

A Decreasing North-to-South Gradient of HFE p.C282Y (rs1800562) Allele Frequencies in Iberia: An Analysis of 34 Population/Control Cohorts.

Genes - 27 Feb 2026

Barton James C, Barton J Clayborn, Acton Ronald T

Abstract excerpt

Background: We sought to analyze the geographic distribution of HFE p.C282Y (homeostatic iron regulator c.845G>A; rs1800562) allele frequencies in Iberia. Methods: We analyzed published population/control cohorts of 50 or more subjects in mainland Spain and mainland Portugal and determined whether or not the p.C282Y genotypes in each cohort deviated from Hardy-Weinberg equilibrium (HWE) proportions. We defined...

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Identifiers

PMID: 41898815
DOI: 10.3390/genes17030277
PMCID: PMC13026221

Genes

HFE

Variants

rs1800562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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