Article
Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72.
Annals of clinical and translational neurology - 1 Dec 2025
Stikvoort García Diederik J L, Goedee H Stephan, van den Berg Leonard H, Sleutjes Boudewijn T H M
Abstract excerpt
OBJECTIVE: We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients. METHODS: We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9+) and 24 were noncarriers (C9-). In addition, 11 C9+ and 110 C9- ALS...
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