Article
A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein.
Blood - 16 Jul 2009
Ueffing Nana, Singh Kusum K, Christians Andrea, Thorns Christoph, Feller Alfred C, Nagl Florian, Fend Falko, Heikaus Sebastian, Marx Alexander, Zotz Rainer B, Brade Joachim, Schulz Wolfgang A, Schulze-Osthoff Klaus, Schmitz Ingo, Schwerk Christian
Abstract excerpt
The cellular FLICE-inhibitory protein (c-FLIP) is a modulator of death receptor-mediated apoptosis and plays a major role in T- and B-cell homeostasis. Three different isoforms have been described on the protein level, including the long form c-FLIP(L) as well as 2 short forms, c-FLIP(S) and the...
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