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GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway

21 Jan 2016

Abstract excerpt

GADD45 gene has been implicated in cell cycle arrest, cell survival or apoptosis in a cell type specific and context-dependent manner. Members of GADD45 gene family have been found differentially expressed in several podocyte injury models, but their roles in podocytes are unclear. Using an in vivo zebrafish model of inducible podocyte injury that we have previously established, we found that zebrafish orthologs...

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PMID: 26794661
DOI: 10.1038/cddis.2015.300

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