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Article

Variants of the IFI16 gene affecting the levels of expression of mRNA are associated with susceptibility to Behçet disease.

The Journal of rheumatology - 1 Apr 2015

Ortiz-Fernández Lourdes, García-Lozano José-Raúl, Montes-Cano Marco-Antonio, Conde-Jaldón Marta, Ortego-Centeno Norberto, García-Hernández Francisco-José, Espinosa Gerard, Graña-Gil Genaro, Sánchez-Bursón Juan, Blanco Ricardo, Barnosi-Marín Ana-Celia, Solans Roser, Fanlo Patricia, Rodríguez-Carballeira Mónica, Camps Teresa, Castañeda Santos, Núñez-Roldán Antonio, Martín Javier, González-Escribano María-Francisca

Abstract excerpt

OBJECTIVE: Behçet disease (BD) is a multifactorial disease in which infectious agents have been proposed as triggers in genetically predisposed individuals. The aim of our study was to investigate the role of innate immunity receptors, specifically the nucleic acid sensors, in susceptibility to BD. METHODS: Seventy-four tag single nucleotide polymorphisms (tSNP) selected in 9 candidate genes (DDX58, IFIH1, TLR3,...

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Source

Identifiers

PMID: 25641891
DOI: 10.3899/jrheum.140949

Genes

IFI16
AIM2
IFIH1
TLR3
TLR7
TLR8
TLR9
ZBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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