Article
Association of MDR1 single-nucleotide polymorphisms and haplotype variants with multiple myeloma in Chinese Jiangsu Han population.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jul 2016
Yin Guangli, Xiao Zhengrui, Ni Ying, Qu Xiaoyan, Wu Hanxin, Lu Hua, Qian Sixuan, Chen Lijuan, Li Jianyong, Qiu Hairong, Miao Kourong
Abstract excerpt
Multidrug resistance 1 (MDR1) gene encodes P-glycoprotein (P-gp), which acts as an efflux pump and provides cell protection against various substances, and its single-nucleotide polymorphisms (SNPs) are associated with the development of malignant hematologic diseases. The present study aimed at investigating whether the MDR1 SNPs and haplotype variants were correlated with the susceptibility to multiple myeloma...
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