Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization

19 Jan 2016

Abstract excerpt

The extracellular matrix polysaccharide hyaluronan (HA) accumulates at sites of autoimmune inflammation, including white matter lesions in multiple sclerosis (MS), but its functional importance in pathogenesis is unclear. We have evaluated the impact of 4-methylumbelliferone (4-MU), an oral inhibitor of HA synthesis, on disease progression in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Glycosylation and Glycoproteins Research
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26787861
DOI: 10.1073/pnas.1525086113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarizationPMID 26787861Read ↗

Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α–dependent pathwaysSemantic proximity Read ↗

Bile Acid Scaffold Engineering Reveals an Androstane-Triol Derivative as a Potent Immunomodulator with Therapeutic Efficacy in EAESemantic proximity Read ↗

Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse modelSemantic proximity Read ↗

Cordycepin Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Leukocyte Infiltration and Reducing NeuroinflammationSemantic proximity Read ↗

Dihydroartemisinin exerts multiple effects in ameliorating CNS inflammation by enhancing AXL signaling in microglia from mouse model of multiple sclerosisSemantic proximity Read ↗

Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

Gene expression analysis reveals functional pathways of glatiramer acetate activationSemantic proximity Read ↗

Regulation of remyelination in multiple sclerosisSemantic proximity Read ↗

The JAK1/3 inhibitor tofacitinib regulates Th cell profiles and humoral immune responses in myasthenia gravisSemantic proximity Read ↗

Dihydroartemisinin Shows Promising Effects in the Treatment of Experimental Autoimmune Encephalomyelitis and Maintains Inflammatory Homeostasis by Targeting AXL in MicrogliaSemantic proximity Read ↗

Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.