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Fertilization defects in sperm from<i>Cysteine-rich secretory protein 2</i>(<i>Crisp2</i>) knockout mice: implications for fertility disorders

19 Jan 2016

Abstract excerpt

STUDY HYPOTHESIS: We hypothesize that fertility disorders in patients with aberrant expression of Cysteine-RIch Secretory Protein 2 (CRISP2) could be linked to the proposed functional role of this protein in fertilization. STUDY FINDING: Our in vivo and in vitro observations reveal that Crisp2-knockout mice exhibit significant defects in fertility-associated parameters under demanding conditions, as well as...

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PMID: 26786179
DOI: 10.1093/molehr/gaw005

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