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Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4

27 Nov 2018

Abstract excerpt

Epididymal Cysteine Rich Secretory Proteins 1 and 4 (CRISP1 and CRISP4) associate with sperm during maturation and play different roles in fertilization. However, males lacking each of these molecules individually are fertile, suggesting compensatory mechanisms between these homologous proteins. Based on this, in the present work, we generated double CRISP1/CRISP4 knockout (DKO) mice and examined their...

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PMID: 30510210
DOI: 10.1038/s41598-018-35719-3

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