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Article

Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.

Scientific reports - 19 Jan 2016

Zheng Xiao, Ma Sijing, Kang An, Wu Mengqiu, Wang Lin, Wang Qiong, Wang Guangji, Hao Haiping

Abstract excerpt

The involvement of systemic immunity in depression pathogenesis promises a periphery-targeting paradigm in novel anti-depressant discovery. However, relatively little is known about druggable targets in the periphery for mental and behavioral control. Here we report that targeting Ly6C(hi) monocytes in blood can serve as a strategy for anti-depressant purpose. A natural compound, ginsenoside Rg1 (Rg1), was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26783261
DOI: 10.1038/srep19406
PMCID: PMC4725984

Genes

CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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