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Brexanolone therapeutics in post-partum depression involves inhibition of systemic inflammatory pathways

16 Feb 2023

Abstract excerpt

BACKGROUND: Brexanolone has rapid, long-lasting, and remarkable efficacy in the treatment of post-partum depression (PPD). We test the hypothesis that brexanolone inhibits proinflammatory modulators and macrophage activation in PPD patients, which may promote clinical recovery. METHODS: PPD patients (N = 18) provided blood samples before and after brexanolone infusion according to the FDA-approved protocol....

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PMID: 36801618
DOI: 10.1016/j.ebiom.2023.104473

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