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Article

miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells.

International journal of oncology - 1 Mar 2016

Nishijima Nobuhiko, Seike Masahiro, Soeno Chie, Chiba Mika, Miyanaga Akihiko, Noro Rintaro, Sugano Teppei, Matsumoto Masaru, Kubota Kaoru, Gemma Akihiko

Abstract excerpt

Nintedanib (BIBF1120) is a multi-targeted angiokinase inhibitor and has been evaluated in idiopathic pulmonary fibrosis and advanced non-small cell lung cancer (NSCLC) patients in clinical studies. In the present study, we evaluated the antitumor effects of nintedanib in 16 NSCLC cell lines and tried to identify microRNA (miRNA) associated with sensitivity to nintedanib. No correlations between FGFR, PDGFR and...

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Source

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Identifiers

PMID: 26783187
DOI: 10.3892/ijo.2016.3331
PMCID: PMC4750530

Genes

ZEB1
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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