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Article

Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression.

Oncotarget - 2 Aug 2016

Englinger Bernhard, Lötsch Daniela, Pirker Christine, Mohr Thomas, van Schoonhoven Sushilla, Boidol Bernd, Lardeau Charles-Hugues, Spitzwieser Melanie, Szabó Pál, Heffeter Petra, Lang Irene, Cichna-Markl Margit, Grasl-Kraupp Bettina, Marian Brigitte, Grusch Michael, Kubicek Stefan, Szakács Gergely, Berger Walter

Abstract excerpt

Genomically amplified fibroblast growth factor receptor 1 (FGFR1) is an oncogenic driver in defined lung cancer subgroups and predicts sensibility against FGFR1 inhibitors in this patient cohort. The FGFR inhibitor nintedanib has recently been approved for treatment of lung adenocarcinoma and is currently evaluated for small cell lung cancer (SCLC). However, tumor recurrence due to development of nintedanib...

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Topics

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Share to Adenocarcinoma of Lung
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Separation

Share to Comparative Genomic Hybridization

Share to Indoles

Share to Neoplasm Recurrence, Local

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Receptors, Endothelin

Source

Open in PubMed Open full text

Identifiers

PMID: 27367030
DOI: 10.18632/oncotarget.10324
PMCID: PMC5226575

Genes

ABCB1
FGFR1
NIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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