Article
Comparison of Magnetic Resonance Imaging and Serum Biomarkers for Detection of Human Pluripotent Stem Cell-Derived Teratomas.
Stem cell reports - 9 Feb 2016
Riegler Johannes, Ebert Antje, Qin Xulei, Shen Qi, Wang Mouer, Ameen Mohamed, Kodo Kazuki, Ong Sang-Ging, Lee Won Hee, Lee Grace, Neofytou Evgenios, Gold Joseph D, Connolly Andrew J, Wu Joseph C
Abstract excerpt
The use of cells derived from pluripotent stem cells (PSCs) for regenerative therapies confers a considerable risk for neoplastic growth and teratoma formation. Preclinical and clinical assessment of such therapies will require suitable monitoring strategies to understand and mitigate these risks. Here we generated human-induced pluripotent stem cells (iPSCs), selected clones that continued to express...
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