Type-2 pericytes participate in normal and tumoral angiogenesis.

doi:10.1152/ajpcell.00084.2014

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Article

Type-2 pericytes participate in normal and tumoral angiogenesis.

American journal of physiology. Cell physiology - 1 Jul 2014

Birbrair Alexander, Zhang Tan, Wang Zhong-Min, Messi Maria Laura, Olson John D, Mintz Akiva, Delbono Osvaldo

Abstract excerpt

Tissue growth and function depend on vascularization, and vascular insufficiency or excess exacerbates many human diseases. Identification of the biological processes involved in angiogenesis will dictate strategies to modulate reduced or excessive vessel formation. We examine the essential role of pericytes. Their heterogeneous morphology, distribution, origins, and physiology have been described. Using...

Topics

Actins
Animals
Antigens
Biomarkers
Brain Neoplasms
Cells, Cultured
Coculture Techniques
Disease Models, Animal
Glioblastoma
Green Fluorescent Proteins
Hindlimb
Human Umbilical Vein Endothelial Cells
Humans
Ischemia

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Luminescent Proteins

Male

Mice

Mice, Inbred C57BL

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Identifiers

PMID: 24788248
DOI: 10.1152/ajpcell.00084.2014
PMCID: PMC4080181

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