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Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm

13 Jan 2016

Abstract excerpt

BACKGROUND: Epigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA). The aim of the study was therefore to investigate histone acetylation and expression of corresponding lysine [K] histone acetyltransferases (KATs) in AAA. RESULTS: A comparative study of AAA tissue samples (n = 37, open surgical intervention) and healthy aortae (n = 12, trauma surgery) was...

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PMID: 26767057
DOI: 10.1186/s13148-016-0169-6

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