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Article

Identification and characterization of novel HLA alleles: Utility of next-generation sequencing methods.

Human immunology - 1 Apr 2016

Brown Nicholas K, Kheradmand Taba, Wang Jinguo, Marino Susana R

Abstract excerpt

The HLA genes are the most polymorphic of the human genome, and novel HLA alleles are continuously identified, often by clinical Sanger sequencing-based typing (SBT) assays. Introduction of next-generation sequencing (NGS) technologies for clinical HLA typing may significantly improve this process. Here we compare four cases of novel HLA alleles identified and characterized by both SBT and NGS. The tested NGS...

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PMID: 26763581
DOI: 10.1016/j.humimm.2016.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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