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Article

Aldosterone resistance: structural and functional considerations and new perspectives.

Molecular and cellular endocrinology - 24 Mar 2012

Zennaro Maria-Christina, Hubert Edwige-Ludiwyne, Fernandes-Rosa Fábio L

Abstract excerpt

Aldosterone plays an essential role in the maintenance of fluid and electrolyte homeostasis in the distal nephron. Loss-of-function mutations in two key components of the aldosterone response, the mineralocorticoid receptor and the epithelial sodium channel ENaC, lead to type 1 pseudohypoaldosteronism (PHA1), a rare genetic disease of aldosterone resistance characterized by salt wasting, dehydration, failure to...

Read the complete abstract on PubMed

Topics

Aldosterone
Animals
Drug Resistance
Epithelial Sodium Channels
Genetic Association Studies
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Models, Biological

Mutant Proteins

Mutation

Protein Interaction Domains and Motifs

Pseudohypoaldosteronism

Receptors, Mineralocorticoid

Structure-Activity Relationship

Water-Electrolyte Balance

Source

Identifiers

PMID: 21664233
DOI: 10.1016/j.mce.2011.04.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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