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Article

Activation of autosomal recessive Pseudohypoaldosteronism1 ENaC with aldosterone.

European journal of pharmacology - 15 Jun 2021

Shabbir Waheed, Topcagic Nermina, Aufy Mohammed

Abstract excerpt

The mineralocorticoid hormone aldosterone stimulates sodium reabsorption in the collecting ducts by increasing the activity of the epithelial sodium channel (ENaC). Being a rate-liming channel the loss of function mutations caused Pseudohypoaldosteronism 1 (PHA1). Despite elevated plasma aldosterone in PHA 1 patients the modulation of PHA 1 causing ENaC mutants with hormone has never been studied. After recording...

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Identifiers

PMID: 33831414
DOI: 10.1016/j.ejphar.2021.174090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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