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Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer

13 Jan 2016

Abstract excerpt

LAMP2A is the key protein of chaperone-mediated autophagy (CMA), downregulation of LAMP2A leads to CMA blockade. CMA activation has been implicated in cancer growth, but the exact mechanisms are unclear. Elevated expression of LAMP2A was found in 8 kinds of tumors (n=747), suggesting that LAMP2A may have an important role in cancer progression. Unsurprisingly, LAMP2A knockdown in gastric cancer (GC) cells...

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PMID: 26761524
DOI: 10.1080/15548627.2015.1136770

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