Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.

doi:10.1093/jnci/djv409

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Article

Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.

Journal of the National Cancer Institute - 1 Jun 2016

Yuan Chen, Clish Clary B, Wu Chen, Mayers Jared R, Kraft Peter, Townsend Mary K, Zhang Mingfeng, Tworoger Shelley S, Bao Ying, Qian Zhi Rong, Rubinson Douglas A, Ng Kimmie, Giovannucci Edward L, Ogino Shuji, Stampfer Meir J, Gaziano John Michael, Ma Jing, Sesso Howard D, Anderson Garnet L, Cochrane Barbara B, Manson JoAnn E, Torrence Margaret E, Kimmelman Alec C, Amundadottir Laufey T, Vander Heiden Matthew G, Fuchs Charles S, Wolpin Brian M

Abstract excerpt

BACKGROUND: Pancreatic tumors cause changes in whole-body metabolism, but whether prediagnostic circulating metabolites predict survival is unknown. METHODS: We measured 82 metabolites by liquid chromatography-mass spectrometry in prediagnostic plasma from 484 pancreatic cancer case patients enrolled in four prospective cohort studies. Association of metabolites with survival was evaluated using Cox proportional...

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PMID: 26755275
DOI: 10.1093/jnci/djv409
PMCID: PMC4849356

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