Article
Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype.
Translational research : the journal of laboratory and clinical medicine - 1 Jan 2024
Yang Jinxi, Shi Na, Wang Shisheng, Wang Manjiangcuo, Huang Yan, Wang Yiqin, Liang Ge, Yang Juqin, Rong Juan, Ma Yun, Li Lan, Zhu Ping, Han Chenxia, Jin Tao, Yang Hao, Huang Wei, Raftery Daniel, Xia Qing, Du Dan
Abstract excerpt
To reveal dysregulated metabolism hallmark that was associated with a severe acute pancreatitis (SAP) phenotype. In this study, LC-MS/MS-based targeted metabolomics was used to analyze plasma samples from 106 acute pancreatitis (AP) patients (34 mild, 38 moderate, and 34 severe) admitted within 48 hours from abdominal pain onset and 41 healthy controls. Temporal metabolic profiling was performed on days 1, 3, and...
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