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Article

Collagens VI and XII form complexes mediating osteoblast interactions during osteogenesis

12 Jan 2016

Abstract excerpt

Bone formation is precisely regulated by cell-cell communication in osteoblasts. We have previously demonstrated that genetic deletion of Col6a1 or Col12a1 impairs osteoblast connections and/or communication in mice, resulting in bone mass reduction and bone fragility. Mutations of the genes encoding collagen VI cause Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM), which have overlapping...

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PMID: 26753503
DOI: 10.1007/s00441-015-2345-y

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