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NOD2 Loss-of-Function Mutations and Risks of Necrotizing Enterocolitis or Focal Intestinal Perforation in Very Low-birth-weight Infants.

Inflammatory bowel diseases - 1 Feb 2016

Härtel Christoph, Hartz Annika, Pagel Julia, Rupp Jan, Stein Anja, Kribs Angela, Müller Andreas, Haase Roland, Gille Christian, Böttger Ralf, Kittel Jochen, Jensen Reinhard, Wieg Christian, Herting Egbert, Göpel Wolfgang

Abstract excerpt

BACKGROUND: NOD2 loss-of-function mutations, that is, R702W [rs2066844], G908R [rs2066845], and Leu1007fsinsC [rs5743293], have been linked to inflammatory bowel diseases. It is yet unknown whether these variants are also associated with necrotizing enterocolitis (NEC) or focal intestinal perforation (FIP) in infants of very low birth weight (VLBW). METHODS: To test this hypothesis, we genotyped 9082 VLBW infants...

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Source

Identifiers

PMID: 26752461
DOI: 10.1097/MIB.0000000000000658

Genes

NOD2

Variants

rs2066844
rs2066844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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