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Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence

11 May 2020

Abstract excerpt

Colonization by pathogenic bacteria depends on their ability to overcome host nutritional defenses and acquire nutrients. The human pathogen group A streptococcus (GAS) encounters the host defense factor calprotectin (CP) during infection. CP inhibits GAS growthin vitroby imposing zinc (Zn) limitation. However, GAS counterstrategies to combat CP-mediated Zn limitation and thein vivorelevance of CP-GAS...

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PMID: 32393509
DOI: 10.1128/iai.00097-20

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