Phthalate Metabolite, Mono(2-Ethyl-5-Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine-Fibroid-Associated Phenotypes in Myometrial Stem Cell-Derived 3D Organoids.

doi:10.1002/tox.70046

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Phthalate Metabolite, Mono(2-Ethyl-5-Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine-Fibroid-Associated Phenotypes in Myometrial Stem Cell-Derived 3D Organoids.

Environmental toxicology - 1 Oct 2026

Vafaei Somayeh, Omran Mervat M, Yang Qiwei, Madueke-Laveaux Sandra, Zota Ami R, Al-Hendy Ayman, Ali Mohamed

Abstract excerpt

This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2-ethylhexyl) phthalate, on myometrial stem cells (MMSCs). MMSCs from normal (MYON) and at-risk (MYOF) uterine tissues were cultured in 3D organoids and treated with 1.6 μM MEHHP for 48 h. Functional assays investigated...

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Topics

Female
Humans
Organoids
Myometrium
Leiomyoma
Apoptosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Stem Cells

Cell Proliferation

Cell Survival

Diethylhexyl Phthalate

Phenotype

Cells, Cultured

Oxidative Stress

Source

Open in PubMed Open full text

Identifiers

PMID: 41621087
DOI: 10.1002/tox.70046
PMCID: PMC13537346

Genes

MYOF
BAX
BCL2
CA9
COL1A1
GPX3
PCNA
TNF

Provenance

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