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Article

Role of gene expression profiling in defining indeterminate thyroid nodules in addition to BRAF analysis.

Cancer cytopathology - 1 May 2016

Borrelli Nicla, Ugolini Clara, Giannini Riccardo, Antonelli Alessandro, Giordano Mirella, Sensi Elisa, Torregrossa Liborio, Fallahi Poupak, Miccoli Paolo, Basolo Fulvio

Abstract excerpt

Fine-needle aspiration (FNA) is routinely used in the preoperative evaluation of thyroid nodules. However, 15% to 30% of aspirations yield indeterminate cytologic findings. Because the assessment of BRAF mutations seems to improve the diagnostic accuracy, this study evaluated BRAF mutations with Sanger sequencing and real-time methods in 650 consecutive thyroid aspirates. In addition, the expression of a large...

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Source

Identifiers

PMID: 26749005
DOI: 10.1002/cncy.21681

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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