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Article

MicroRNA-30b targets Snail to impede epithelial-mesenchymal transition in pancreatic cancer stem cells

1 Jan 2018

Abstract excerpt

Snail-mediated epithelial-mesenchymal transition (EMT) process plays a fundamental role in facilitating pancreatic ductal adenocarcinoma (PDAC) stemness and metastasis. In the present study, we revealed that microRNA-30 (miR-30) members, especially miR-30b, were remarkably downregulated in triple-positive (CD24 + , CD44 + , EpCAM + ) pancreatic cancer stem cells (PCSCs). In addition, we revealed that miR-30b...

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PMID: 29937934
DOI: 10.7150/jca.25006

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