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Article

Treatment and molecular monitoring update in chronic myeloid leukemia management.

Annales de biologie clinique - 1 Apr 2017

Sorel Nathalie, Cayssials Émilie, Brizard Françoise, Chomel Jean-Claude

Abstract excerpt

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm resulting from the t(9;22)(q34;q11) translocation. It is characterized by the presence of the BCR-ABL1 fusion gene encoding the BCR-ABL oncoprotein characterized by a deregulated tyrosine kinase activity. Targeted therapies using tyrosine kinase inhibitors (TKI) such as imatinib, dasatinib, nilotinib, bosutinib, or ponatinib have profoundly changed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Identifiers

PMID: 28377326
DOI: 10.1684/abc.2017.1233

Genes

BCR
ABL1

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