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Article

The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease.

Parkinsonism & related disorders - 1 Feb 2016

Tekin Izel, Carkaci-Salli Nurgul, Lewis Mechelle M, Mailman Richard B, Huang Xuemei, Vrana Kent E

Abstract excerpt

INTRODUCTION: Many of the symptoms and signs of Parkinson's disease (PD) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis. METHODS: We investigated whether the presence of a common TH polymorphism affects the clinical outcomes in 101 PD subjects. We further examined the effect of this polymorphism on the purified...

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Identifiers

PMID: 26732803
DOI: 10.1016/j.parkreldis.2015.12.015
PMCID: PMC4770791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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