Article
Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome.
Stem cells and development - 1 Mar 2016
Moschidou Dafni, Corcelli Michelangelo, Hau Kwan-Leong, Ekwalla Victoria J, Behmoaras Jacques V, De Coppi Paolo, David Anna L, Bou-Gharios George, Cook H Terence, Pusey Charles D, Fisk Nicholas M, Guillot Pascale V
Abstract excerpt
Alport syndrome (AS) is a hereditary glomerulopathy caused by a mutation in type IV collagen genes, which disrupts glomerular basement membrane, leading to progressive glomerulosclerosis and end-stage renal failure. There is at present no cure for AS, and cell-based therapies offer promise to improve renal function. In this study, we found that human first trimester fetal chorionic stem cells (CSC) are able to...
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