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Stem Cell Therapies Benefit Alport Syndrome

15 Oct 2009

Abstract excerpt

Patients with Alport syndrome progressively lose renal function as a result of defective type IV collagen in their glomerular basement membrane. In mice lacking the alpha3 chain of type IV collagen (Col4A3 knockout mice), a model for Alport syndrome, transplantation of wild-type bone marrow repairs the renal disease. It is unknown whether cell-based therapies that do not require transplantation have similar...

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PMID: 19833902
DOI: 10.1681/asn.2009010123

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