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Article

HER2 Amplification and HER2 Mutation Are Distinct Molecular Targets in Lung Cancers.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2016

Li Bob T, Ross Dara S, Aisner Dara L, Chaft Jamie E, Hsu Meier, Kako Severine L, Kris Mark G, Varella-Garcia Marileila, Arcila Maria E

Abstract excerpt

INTRODUCTION: Human epidermal growth factor receptor 2 gene (HER2 [also known as ERBB2]) alterations have been identified as oncogenic drivers and potential therapeutic targets in lung cancers. The molecular associations of HER2 gene amplification, mutation, and HER2 protein overexpression in lung cancers have not been distinctly defined. To explore these associations, Memorial Sloan Kettering Cancer Center and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, erbB-2

Share to In Situ Hybridization, Fluorescence

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Share to Receptor, ErbB-2

Source

Open in PubMed Open full text

Identifiers

PMID: 26723242
DOI: 10.1016/j.jtho.2015.10.025
PMCID: PMC4698879

Genes

ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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