Article
Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma.
Anticancer research - 1 Jan 2016
Isohookana Joel, Haapasaari Kirsi-Maria, Soini Ylermi, Karihtala Peeter
Abstract excerpt
BACKGROUND: The role of the redox-regulating peroxiredoxin (Prx) enzymes I-VI in pancreatic carcinoma is poorly characterized. MATERIALS AND METHODS: The expression of Prxs I, II, III, V and VI was immunohistochemically evaluated in benign pancreas and in 69 pancreatic adenocarcinoma samples. RESULTS: Cytoplasmic Prx I expression was significantly greater in cancer cells than in benign pancreas (p=0.002) and Prx...
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