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Article

Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.

Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2016

Wang Chunmei, Che Li, Hu Junjie, Zhang Shanshan, Jiang Lijie, Latte Gavinella, Demartis Maria I, Tao Junyan, Gui Bing, Pilo Maria G, Ribback Silvia, Dombrowski Frank, Evert Matthias, Calvisi Diego F, Chen Xin

Abstract excerpt

BACKGROUND & AIMS: Activating mutations of PIK3CA occur in various tumour types, including human hepatocellular carcinoma. The mechanisms whereby PIK3CA contributes to hepatocarcinogenesis remain poorly understood. METHODS: PIK3CA mutants H1047R or E545K were hydrodynamically transfected, either alone or in combination with NRasV12 or c-Met genes, in the mouse liver. RESULTS: Overexpression of H1047R or E545K...

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Share to Carcinoma, Hepatocellular
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Identifiers

PMID: 26716908
DOI: 10.1111/liv.13055
PMCID: PMC4929046

Genes

AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.PMID 26716908Read ↗

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