Article

RASSF1A independence and early Galectin-1 upregulation in PIK3CA induced hepatocarcinogenesis: new therapeutic venues

2021-06-15

Abstract excerpt

Aberrant activation of the PI3K/AKT/mTOR and Ras/Mitogen-Activated Protein Kinase pathways is a hepatocarcinogenesis hallmark. In a subset of hepatocellular carcinomas (HCC), PI3K/AKT/mTOR signaling dysregulation depends on PIK3CA mutations, while RAS/MAPK activation is partly attributed to promoter methylation of the tumor suppressor RASSF1A . To evaluate a possible co-carcinogenic effect of PIK3CA activation an...

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Literature Corpus work: 49737178-405d-5011-97bd-c9cddda480e3
DOI: 10.1101/2021.06.15.448477

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