RASSF1A independence and early Galectin-1 upregulation in PIK3CA induced hepatocarcinogenesis: new therapeutic venues

Abstract excerpt

Aberrant activation of the PI3K/AKT/mTOR and Ras/Mitogen-Activated Protein Kinase pathways is a hepatocarcinogenesis hallmark. In a subset of hepatocellular carcinomas (HCC), PI3K/AKT/mTOR signaling dysregulation depends on PIK3CA mutations, while RAS/MAPK activation is partly attributed to promoter methylation of the tumor suppressor RASSF1A . To evaluate a possible co-carcinogenic effect of PIK3CA activation an...

Topics

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• Carcinogenesis
• Carcinoma, Hepatocellular
• Class I Phosphatidylinositol 3-Kinases
• Liver Neoplasms
• Phosphatidylinositol 3-Kinases
• Proto-Oncogene Proteins c-akt
• TOR Serine-Threonine Kinases
• Up-Regulation

Identifiers and source

Literature Corpus work

49737178-405d-5011-97bd-c9cddda480e3

DOI

10.1101/2021.06.15.448477