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Determination of ETV 6‐ RUNX 1 genomic breakpoint by next‐generation sequencing

29 Dec 2015

Abstract excerpt

The t(12;21)(p13;q22) ETV6-RUNX1 gene fusion is one of the most common chromosomal translocation in childhood acute lymphoblastic leukemia (ALL). It is associated with favorable prognosis. The identification of the genomic sequence of the breakpoint flanking regions of the ETV6-RUNX1 translocation should be the best strategy to monitor minimal residual disease (MRD) in patients with ETV6-RUNX1-positive ALL. In...

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PMID: 26711002
DOI: 10.1002/cam4.579

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