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Article

The legacy of domestication: accumulation of deleterious mutations in the dog genome.

Molecular biology and evolution - 1 Nov 2008

Cruz Fernando, Vilà Carles, Webster Matthew T

Abstract excerpt

Dogs exhibit more phenotypic variation than any other mammal and are affected by a wide variety of genetic diseases. However, the origin and genetic basis of this variation is still poorly understood. We examined the effect of domestication on the dog genome by comparison with its wild ancestor, the gray wolf. We compared variation in dog and wolf genes using whole-genome single nucleotide polymorphism (SNP)...

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PMID: 18689870
DOI: 10.1093/molbev/msn177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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