Article
Physician response to implementation of genotype-tailored antiplatelet therapy.
Clinical pharmacology and therapeutics - 1 Jul 2016
Peterson J F, Field J R, Unertl K M, Schildcrout J S, Johnson D C, Shi Y, Danciu I, Cleator J H, Pulley J M, McPherson J A, Denny J C, Laposata M, Roden D M, Johnson K B
Abstract excerpt
Physician responses to genomic information are vital to the success of precision medicine initiatives. We prospectively studied a pharmacogenomics implementation program for the propensity of clinicians to select antiplatelet therapy based on CYP2C19 loss-of-function variants in stented patients. Among 2,676 patients, 514 (19.2%) were found to have a CYP2C19 variant affecting clopidogrel metabolism. For the...
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