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Article

Acquired deficiency of tafazzin in the adult heart: Impact on mitochondrial function and response to cardiac injury.

Biochimica et biophysica acta - 1 Apr 2016

Szczepanek Karol, Allegood Jeremy, Aluri Hema, Hu Ying, Chen Qun, Lesnefsky Edward J

Abstract excerpt

The content and composition of cardiolipin (CL) is critical for preservation of mitochondrial oxidative phosphorylation (OXPHOS) and inner membrane integrity. Tafazzin (Taz) is an enzyme responsible for remodeling of immature CL containing mixed acyl groups into the mature tetralinoleyl form (C18:2)4-CL. We hypothesized that acquired defects in Taz in the mature heart would impact remodeling of CL and augment...

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Source

Identifiers

PMID: 26692032
DOI: 10.1016/j.bbalip.2015.12.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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