Article
Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses.
Nature genetics - 1 Feb 2016
Imsland Freyja, McGowan Kelly, Rubin Carl-Johan, Henegar Corneliu, Sundström Elisabeth, Berglund Jonas, Schwochow Doreen, Gustafson Ulla, Imsland Páll, Lindblad-Toh Kerstin, Lindgren Gabriella, Mikko Sofia, Millon Lee, Wade Claire, Schubert Mikkel, Orlando Ludovic, Penedo Maria Cecilia T, Barsh Gregory S, Andersson Leif
Abstract excerpt
Dun is a wild-type coat color in horses characterized by pigment dilution with a striking pattern of dark areas termed primitive markings. Here we show that pigment dilution in Dun horses is due to radially asymmetric deposition of pigment in the growing hair caused by localized expression of the T-box 3 (TBX3) transcription factor in hair follicles, which in turn determines the distribution of hair follicle...
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