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Bromodomain and hedgehog pathway targets in small cell lung cancer

15 Dec 2015

Abstract excerpt

Small cell lung cancer (SCLC) is an extremely aggressive cancer that frequently recurs. Twenty-three human SCLC lines were selected representing varied Myc status. Gene expression of lung cancer, stem-like, hedgehog pathway, and notch pathway genes were determined by RT(2)-PCR array and Exon 1.0 ST array. Etoposide and topotecan concentration response was examined. The IC50's for etoposide and topotecan ranged...

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PMID: 26683772
DOI: 10.1016/j.canlet.2015.12.001

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