Article
Phenotypic and functional abnormalities of bone marrow-derived dendritic cells in systemic lupus erythematosus.
Arthritis research & therapy - 1 Jan 2010
Nie Ying J, Mok Mo Y, Chan Godfrey C F, Chan Albert W, Jin O U, Kavikondala Sushma, Lie Albert K W, Lau Chak S
Abstract excerpt
INTRODUCTION: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoreactive T and B cells, which are believed to be secondary to deficient dendritic cells (DCs). However, whether DC abnormalities occur during their development in the bone marrow (BM) or in the periphery is not known. METHODS: Thirteen patients with SLE and 16 normal controls were recruited. We studied the morphology,...
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